Serophene® (clomiphene citrate tablets USP)

FAQ's

Why has my healthcare provider prescribed Serophene® (clomiphene citrate tablets USP) and how does it work?
How is Serophene® administered?
How many cycles of Serophene® should I take?
Who should not use Serophene®?
Are there any side effects associated with Serophene®?
Is Serophene® associated with multiple births?
Is Serophene® associated with congenital birth defects?
Is Serophene® associated with ovarian cancer?

Why has my healthcare provider prescribed Serophene® (clomiphene citrate tablets USP) and how does it work?top ^

Serophene® is typically considered an initial therapy for patients experiencing ovulatory failure or dysfunction. Serophene® works by stimulating the body to release follicle stimulating hormone (FSH) and luteinizing hormone (LH), the hormones necessary for ovulation to occur.

How is Serophene® administered?top ^

Serophene® is an orally administered drug.

How many cycles of Serophene® should I take?top ^

Serophene® (clomiphene citrate tablets USP) has been proven safe and effective in clinical trials. However, the American Society for Reproductive Medicine recommends that treatment with Serophene® (clomiphene citrate tablets USP) be limited to no more than six ovulatory cycles. If a patient fails to conceive after successful clomiphene citrate–induced ovulation, a Fertility Specialist, also called a Reproductive Endocrinologist (RE) may conduct further evaluation. And frequently, a more advanced treatment, such as FSH, is recommended.

Who should not use Serophene®?

You should not use Serophene® if you answer "yes" to any of the following questions. If you are unsure if you should use Serophene®, talk with your healthcare provider.

• Do you have allergies to clomiphene citrate preparations or their ingredients?
• Are you pregnant?

Prolonged use of Serophene® may increase the risk of ovarian cancer.

Are there any side effects associated with Serophene®?top ^

You should review with your Fertility Specialist the risks and benefits of using Serophene®. As with any medication, report any and all side effects, symptoms or physical changes to your healthcare provider.

Serophene® can cause serious side effects including ovarian hyperstimulation syndrome (OHSS) and lung and blood vessel complications.

As with all medications, it is important to report any physical changes and all symptoms to your healthcare provider. With Serophene® you should be aware that blurring or other visual symptoms may occur. These may make activities such as driving or operating machinery more hazardous than usual, particularly under conditions of variable lighting. While their significance is not yet understood, patients having any visual symptoms should discontinue treatment and have a complete ophthalmologic evaluation.

Pregnancy loss (miscarriage) is higher in women receiving fertility drugs than in women not taking fertility drugs.

The most common side effects include hot flashes, stomach discomfort and bloating, nausea and vomiting, breast discomfort, headache, and vaginal bleeding. For complete product details, see the Full Prescribing Information.

Is Serophene® associated with multiple births?top ^

Multiple births have been associated with the use of fertility medications. You should discuss the potential risk of multiple births with your fertility team before beginning treatment.

Is Serophene® associated with congenital birth defects?top ^

The incidence of birth defects associated with Serophene® is no different from that of the untreated population.

Is Serophene® associated with ovarian cancer?top ^

Prolonged use of clomiphene citrate may increase the risk of a borderline or invasive ovarian tumor. A causal association between fertility medications and ovarian cancer has not been established.

If you have any additional questions, be sure to contact your Fertility Specialist for more information or guidance. You can also call Fertility LifeLines™ toll–free at 1–866–LETS-TRY (1-866-538-7879). All calls are free and confidential.

Full Prescribing Information for Serophene® (clomiphene citrate tablets USP) (85 KB)