Cetrotide® (cetrorelix acetate for injection)

Cetrotide® is the first and only gonadotropin releasing hormone antagonist that offers dosing simplicity and flexibility. It is injected subcutaneously (just under the skin). Cetrotide is available in a 3 mg single–dose regimen and a 0.25 mg daily dose given on stimulation day 5 or 7 depending on the strength.

Why Cetrotide® is used.

Cetrotide® helps control your body's hormonal responses, which affect the development of eggs.

Specifically, Cetrotide® helps delay a hormonal event known as the "LH surge".

The LH surge is caused by a series of changes involving two hormones—gonadotropin–releasing hormone (GnRH) and luteinizing hormone (LH). When GnRH is present, it triggers a dramatic rise, or "surge" in LH levels. However, if an LH surge occurs too early in a cycle, your eggs will be released before they're expected.

Cetrotide® works by directly blocking the trigger effect of GnRH. This blocking action stops the premature LH surge in women undergoing controlled ovarian stimulation before they begin. In doing so, this allows eggs to reach the level of development needed for fertilization.

Ask your healthcare provider if Cetrotide® is right for you.

• Cetrotide® Instructions for Use

If you have questions about Cetrotide® or any other EMD Serono fertility product, call Fertility LifeLines™ at 1–866–LETS TRY (1–866–538–7879). All calls are free and confidential.

EMD Serono fertility products in the infertility treatment cycle

Important Safety Information

Cetrotide® should only be prescribed by doctors specializing in infertility or reproductive health. Cetrotide can cause serious side effects including ovarian hyperstimulation syndrome (OHSS), with or without blood vessel and lung complications, and multiple births. Cetrotide® should not be used in women who, are allergic to cetrorelix acetate, mannitol or exogenous peptide hormones (medicines similar to Cetrotide®), who have kidney disease, are pregnant or think they are pregnant, or are breast-feeding. Mild and short lasting injection reactions like reddening, itching and swelling at the injection sites have occurred in women using Cetrotide®. Nausea and headache have also been reported. Please see the Full Prescribing Information, and FAQ's for more information.