Cetrotide® (cetrorelix acetate for injection)

FAQ's

What is Cetrotide®?
What is the LH Surge and how does it affect infertility?
How does Cetrotide® prevent the LH surge?
When should I use Cetrotide®?
Which dosing regimen of Cetrotide® should I choose?
How is Cetrotide® administered?
Who should not use Cetrotide®?
Are there any side effects associated with the use of Cetrotide®?
Where can I get more information about Cetrotide®?
How long can I keep Cetrotide® after it has been reconstituted?

What is Cetrotide®?top ^

Cetrotide® is an injectable drug that controls hormonal responses in your body, which can affect the development of eggs in your ovaries. Specifically, Cetrotide® helps to prevent a hormonal event known as the "LH surge."

What is the LH Surge and how does it affect infertility?top ^

The LH Surge is a natural hormonal response that signals the release of a mature egg from an ovary. While undergoing infertility treatment, if an LH surge occurs too early in a cycle, eggs are released before they can fully mature. This greatly reduces the opportunity to retrieve the eggs for later use in Assisted Reproductive Technologies (ART). The LH surge is caused by a series of changes involving two hormones — gonadotropin — releasing hormone (GnRH) and luteinizing hormone (LH). When GnRH is present, it triggers a dramatic rise, or "surge," in LH levels.

How does Cetrotide® prevent the LH surge?top ^

Cetrotide® works by directly blocking the trigger effect of GnRH. This blocking action stops a possible LH surge before it begins, allowing eggs to reach the level of development needed for fertilization. Because of the way it works, Cetrotide® is called a GnRH antagonist.

When should I use Cetrotide®?top ^

You only need to use Cetrotide® for the short part of your cycle in which an LH surge is a concern. This is the part of your cycle when your eggs are nearing maturity.

Which dosing regimen of Cetrotide® should I choose?top ^

Cetrotide® is available in two dosing regimens — a single dose (3 mg), which controls the LH surge for up to 4 days, or a daily dose (0.25 mg) given over a short period of time. Your healthcare provider has chosen the regimen that best meets your individual needs. Be sure to follow your healthcare provider's specific instructions for dose strength and schedule.

How is Cetrotide® administered?top ^

Cetrotide® is given as a subcutaneous (under the skin) injection.

Who should not use Cetrotide®?top ^

You should not use Cetrotide® if you answer "yes" to any of the following questions. If you are unsure if you should use Cetrotide®, talk with your healthcare provider.

• Do you have a known allergy to cetrorelix acetate, GnRH or any other GnRH analogs, exogenous peptide hormones or mannitol?
• Are you pregnant or do you suspect you may be pregnant?
• Are you currently breast-feeding?
• Do you have severe renal impairment?

Are there any side effects associated with the use of Cetrotide®?top ^

You should review with your Fertility Specialist the risks and benefits of using Cetrotide®. As with any medication, report any and all side effects, symptoms or physical changes to your healthcare provider.

Cetrotide® can cause serious side effects including ovarian hyperstimulation syndrome (OHSS) and lung and blood vessel problems.

Pregnancy loss (miscarriage) is higher in women receiving fertility drugs than in women not taking fertility drugs.

Because it acts quickly and directly, Cetrotide® is generally well tolerated. The most common side effects include mild and short-lasting reactions, like reddening, itching, and swelling, may occur at the injection site. Some patients also experience nausea and headaches. For complete product details, see the Full Prescribing Information.

Where can I get more information about Cetrotide®?top ^

If you have any questions, be sure to contact your Fertility Specialist for more information or guidance. You can also call EMD Serono Fertility LifeLines™ toll–free at 1–866–LETS-TRY (1–866–538–7879).

How long can I keep Cetrotide® after it has been reconstituted?top ^

The solution should be used immediately after preparation.

If you have any additional questions, be sure to contact your Fertility Specialist for more information or guidance. You can also call Fertility LifeLines™ toll–free at 1–866–LETS-TRY (1-866-538-7879). All calls are free and confidential.

Full Prescribing Information for Cetrotide® (cetrorelix acetate for injection) (376 KB)

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