Assisted Reproductive Technologies

Donation

Egg donation involves one woman (a donor) "donating" her eggs so that another woman (a recipient) might be able to conceive.

In egg donation, in vitro fertilization (IVF) is performed in the usual manner, except that the donor may receive fertility medications to stimulate the production of multiple eggs in her ovaries. At the same time, the recipient may also receive medications so that her cycle mirrors the cycle of the donor and her body is prepared to receive the embryo. The egg is then fertilized in a laboratory and the embryos are implanted in the recipient's uterus.

Egg donation candidates

Generally, egg donation may be an option for a woman who:

  • Is older and has not succeeded with other therapies
  • Has reached menopause prematurely
  • May carry a genetic disorder that was determined through blood testing
  • Has experienced unexplained and repeated miscarriages

To learn more about egg donation, or to determine if you are an appropriate candidate, talk to your healthcare provider. You may also wish to learn about the donor process — how donors are found, what screening is required and what information you may receive about the donor.

Sperm donation

Using donated sperm is an option if the male partner:

  • Has no sperm or very poor-quality sperm
  • Has undergone previous radiation or chemotherapy treatment
  • Has a genetic disorder that might be inherited that he does not want to pass on to his unborn child.

Donor insemination is also a possible option for single women and same-sex couples who want a child.

Embryo donation

Embryo donation involves donor eggs that have been fertilized with sperm by the donor's partner or with donor sperm. Some women who undergo IVF may choose to donate the fertilized eggs not used in their cycle. The donated embryos are then transferred to the recipient's uterus.

Surrogacy

Surrogacy involves one woman carrying a pregnancy for another woman. There are two types of surrogacy:

  • Gestational surrogacy involves a woman carrying a pregnancy created by the egg and the sperm of two other people. For instance, in the case of a woman with functioning ovaries but without a uterus, or with a malformed uterus, she and her partner may opt to use IVF, then have the resulting embryo transferred into a gestational surrogate.
  • Traditional surrogacy involves insemination with the sperm from the male partner of an infertile couple. The female partner or couple must legally adopt the child after birth.

Emotional aspects of donation or surrogacy

Undergoing fertility treatments can sometimes be an emotional, frustrating process. Deciding whether or not to use donation or surrogacy can cause additional levels of complexity to surface in your relationship. For this reason, you and your partner should consider seeking psychological counseling before undertaking this procedure.

In addition, donation and surrogacy are often surrounded with complicated legal issues. It's a good idea to consult an attorney knowledgeable in this area before proceeding with third-party reproduction.

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Indication:
For women, Gonal-f® (follitropin alfa for injection), Gonal-f® RFF (follitropin alfa injection) and Gonal-f® RFF Pen (follitropin alfa injection) are indicated for 1) the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure and 2) for the development of multiple follicles in the ovulatory patient participating in an Assisted Reproductive Technology (ART) program.
For men, Gonal-f® is also indicated for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the main cause of infertility is not due to primary testicular failure.

Important Safety Information:
These products should only be prescribed by physicians specializing in fertility or reproductive health. Use of Gonal-f® or Gonal-f® RFF by women can result in multiple births. Patients should let their doctor know of any allergic reactions to recombinant FSH preparations or other product ingredients. Patients should also inform their doctor of a history of cancer of the sex organs or brain and uncontrolled thyroid or adrenal disease before starting or continuing treatment. Women with a history of abnormal bleeding from the uterus or vagina, swollen, enlarged, or painful ovaries should speak to their doctor before starting treatment. Gonal-f® and Gonal-f® RFF are potent gonadotropic substances capable severe adverse reactions, including Ovarian Hyperstimulation Syndrome (OHSS) in women, which can result hospitalization. Women should inform their doctor if they experience severe stomach pain, vomiting, bloating, or weight gain while taking Gonal-f® or Gonal-f RFF®. The most common side effects are headache, ovarian cysts, upset stomach, and sinus infections in women taking Gonal-f® or Gonal-f® RFF. The most common side effects in men taking Gonal-f® are skin acne, breast pain and growth, and tiredness. Needle injections may cause some discomfort.

For more information, refer to the prescribing and patient information offered below and talk to your doctor.


© EMD Serono, Inc. CIM Last Update 2008-09-16
This site contains medical information that is intended for residents of the United States only and is not meant to substitute for the advice provided by a medical professional. Always consult a physician if you have health concerns. Use and access of this site is subject to the terms and conditions as set out in our Legal Statement and Privacy Policy.

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