Basic Biology

Female Biology

A female is born with over 1 million eggs in her ovaries. This amount will never increase.

Diagram of the female reproductive systemBy the time she reaches puberty, she'll have about 300,000 eggs left. Of these, only about 300 eggs will mature and be released during her reproductive years. All eggs are stored in a woman's ovaries.1

Cycle of life

A woman's monthly menstrual cycle drives her ability to conceive. The cycle begins on the first day of a woman's period and typically lasts about 28 days. The first day occurs not with spotting, but when there is a regular flow.

The menstrual cycle has three distinct phases: the follicular phase, the ovulatory phase, and the luteal phase.

Natural Monthly Cycle

View the day-by-day animation of a woman's natural monthly cycle.

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Follicular Phase: Days 1–14

During the first 13 days of a woman's cycle, follicle stimulating hormone (FSH) causes her body to create a fluid-filled sac, or follicle in one of her ovaries. This follicle then produces a single mature egg. While this happens, the follicle releases another hormone called estrogen. Estrogen helps the cervical mucus at the entrance of her uterus to receive sperm. The endometrium also begins to thicken during this phase.

A rise in luteinizing hormone (LH) helps the egg reach maturity and on about the 14th day, triggers ovulation. At this time, an ovary releases the egg which then travels down a fallopian tube. When a couple has intercourse, a man's sperm tries to swim past the cervical mucus and into the fallopian tube where it can fertilize the egg. The best days for conception are generally days 11 to 17 — the ones just before and after ovulation.

Luteal Phase: Days 15–28

After ovulation, the hormones progesterone and estrogen help the endometrium receive the fertilized egg. The fertilized egg, or embryo then travels down the fallopian tubes to implant itself in the endometrium on about the 20th day of the cycle. There, it will develop into a fetus.

If the egg isn't fertilized, it passes through a woman's body on about the 26th day. The uterus then sheds its lining and a woman's period begins, starting a new menstrual cycle.

It is important to understand that 28 days is just an average. Not every woman has a 28-day cycle. The specific days of your Follicular and Luteal phases may be different. For more information, talk to your healthcare provider or call Fertility LifeLines™ at 1-866-LETS-TRY (1-866-538-7879).

Hormones' critical role

Sound complex? It is! Each step in the cycle is controlled by hormones. In order for a woman to conceive, the conditions must be just right. Hormones must be made in the correct amounts and at the right times. Any interruptions can disrupt a woman's ability to conceive. In addition, other factors may play a role in reducing fertility, such as age and lifestyle choices.

  • 1. American Society for Reproductive Medicine. Age and fertility: A guide for patients. Birmingham, Alabama: American Society for Reproductive Medicine; 2003.

See for Yourself

Watch how a woman's monthly cycle progresses, day by day.
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Indication:
For women, Gonal-f® (follitropin alfa for injection), Gonal-f® RFF (follitropin alfa injection) and Gonal-f® RFF Pen (follitropin alfa injection) are indicated for 1) the induction of ovulation and pregnancy in the anovulatory infertile patient in whom the cause of infertility is functional and not due to primary ovarian failure and 2) for the development of multiple follicles in the ovulatory patient participating in an Assisted Reproductive Technology (ART) program.
For men, Gonal-f® is also indicated for the induction of spermatogenesis in men with primary and secondary hypogonadotropic hypogonadism in whom the main cause of infertility is not due to primary testicular failure.

Important Safety Information:
These products should only be prescribed by physicians specializing in fertility or reproductive health. Use of Gonal-f® or Gonal-f® RFF by women can result in multiple births. Patients should let their doctor know of any allergic reactions to recombinant FSH preparations or other product ingredients. Patients should also inform their doctor of a history of cancer of the sex organs or brain and uncontrolled thyroid or adrenal disease before starting or continuing treatment. Women with a history of abnormal bleeding from the uterus or vagina, swollen, enlarged, or painful ovaries should speak to their doctor before starting treatment. Gonal-f® and Gonal-f® RFF are potent gonadotropic substances capable severe adverse reactions, including Ovarian Hyperstimulation Syndrome (OHSS) in women, which can result hospitalization. Women should inform their doctor if they experience severe stomach pain, vomiting, bloating, or weight gain while taking Gonal-f® or Gonal-f RFF®. The most common side effects are headache, ovarian cysts, upset stomach, and sinus infections in women taking Gonal-f® or Gonal-f® RFF. The most common side effects in men taking Gonal-f® are skin acne, breast pain and growth, and tiredness. Needle injections may cause some discomfort.

For more information, refer to the prescribing and patient information offered below and talk to your doctor.


© EMD Serono, Inc. CIM Last Update 2008-09-16
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